Monteloeder, a subsidiary of Spanish nutraceutical ingredients provider Suannutra, has announced promising study results for its natural formulation, Nutroxsun.
The study, published in the International Journal of Molecular Sciences last month, explores Nutroxsun’s photoprotective potential.
Nutroxsun is a unique combination of extracts of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradise).
The study results highlighted the supplement’s potential in helping maintain youthful-looking skin under ultraviolet (UV) exposure, offering scientific support for its role in skin health.
In-vitro analysis on UV-exposed human dermal fibroblasts showed that the composition can reduce oxidative stress markers and inflammation while supporting skin structural integrity.
Monteloeder chief R&D officer Nuria Caturla said: “Skin redness are the most noticeable and immediate inflammatory reaction to solar radiation. It usually appears 3-5 hours after exposure and peaks at 12–24 hours, fading gradually over 72 hours.”
“The results from the present study reinforce and expand on previous evidence supporting Nutroxsun’s role in helping improve skin health and appearance when exposed to UV-related stressors.
“Rosemary extracts have been shown to help slow down collagen degradation further highlighting their potential to support dermal structure and resilience.
“Grapefruit flavones have been studied for their role in counteracting UVB-induced oxidative effects that may impact collagen integrity helping protect the skin by stopping UVB rays from breaking down collagen.”
A subsequent placebo-controlled, crossover clinical trial in 20 volunteers assessed Nutroxsun’s efficacy in mitigating UV-induced redness and skin recovery post-exposure.
Participants received either 100mg or 250mg of Nutroxsun or a placebo. Results indicated a milder increase in redness for those taking Nutroxsun compared to the placebo group.
In the study, redness increased by 62.7% in the placebo group, while the Nutroxsun 100mg and 250mg groups showed increases of 44.7% and 41.0%, respectively.
Redness in both Nutroxsun groups nearly returned to baseline within 72 hours, unlike the placebo group, which still exhibited elevated levels.
Further analysis revealed that fair-skinned participants benefited more from the 250mg dose, showing lower redness at all time points.
The study builds on previous trials, including one with 90 participants, which reported reduced skin lipid peroxidation and improvements in skin texture, wrinkles, and elasticity.
Participants in the earlier trial noted their skin felt more moisturised, with 77% observing improved skin appearance and tone.
In addition, 73% reported firmer skin, and 60% saw a visible reduction in wrinkles.
Suannutra science marketing manager Mariana Ortega said: “Nutroxsun was developed as a dietary solution to support the skin’s natural defence mechanisms in response to UV-induced oxidative stress.
“It acts from within to help maintain skin health when exposed to environmental aggressors. Rosemary and grapefruit extracts contain phenolic compounds that work synergistically to help neutralise free radicals generated by UV exposure.
“These effects are relevant to both short-term/ immediate responses, such as redness, and long-term factors associated with visible signs of photoaging, including collagen and elastin changes.”
