Gnosis is pleased to announce that Quatrefolic®, the biologically active form of the naturally-occurring predominant form of folate, has been approved as a Non-Traditional Food Ingredient by the Ministry of Health and Welfare in Taiwan (FDA Document No. 1071300010 issued on 21 March 2018).

Applications on use of the Glucosamine Salt of the (6S)-5-Methyl-tetrahydrofolic acid – the food ingredient known as Gnosis’ Quatrefolic® – have been properly defined and published in the relevant specifications, which claim compliance of our product with folic acid standards.

Due to its unique features, Quatrefolic® is recommended during all stages of life and also to those individuals affected by MTHFR enzyme polymorphism who do not produce adequate or effective methyltetrahydrofolate Reductase, thus encountering all health problems associated with the lack of vitamin B9.

"Geographical and ethnic distribution of MTHFR polymorphisms have been widely investigated in the last years. Taiwanese population owns to Han ethnicity. Published data in 2017 shows that the frequency of MTHFR polymorphisms is expressed by the 26.1% of the population, in subjects with heterozygous genotype (Yang B. et al. Clin Genet 2017)" said Silvia Pisoni, marketing manager of Gnosis. "Quatrefolic® is the first choice in the folate supplementation because it maximizes the benefit of folate supplementation, protecting naturally all people without the need to identify the presence of MTHFR".

For more information, please read the official notice, published on 21 March in the TFDA website (link available at