Gnosis steadily invests in science to discover and raise awareness of what is going on in the world of folates, emphasising scientifically proven aspects of the role of Quatrefolic® (5-methyltetrahydrofolate glucosamine salt) in health and bringing to light the new emerging breakthrough for new applications in wellbeing and health.

Over the past several decades, folate has emerged as an important nutrient in several key conditions of concern to the elderly. Older individuals are especially exposed to folate deficiency and often normal/subnormal folate levels do not exclude tissue deficiency.

Folate (especially the biologically active form as Quatrefolic®) has got an increased interest as it reflects the intracellular interaction of plasma homocysteine (Hcy) metabolism of the "methylation cycle" and is considered to mirror the functional relations close to the cells and therefore the health in aging population.

Quatrefolic®, "the innovactive folate", is structurally analogous to the reduced and active form of folate, so Quatrefolic® completely bypasses the conversion steps and delivers a "finished" folate that the body can immediately use without any kind of metabolisation.

Folic acid is not biologically active and needs to be converted to the metabolically active 5-methyltetrahydrofolate (5-MTHF) through a multi-step process; some individuals, due to their unique genetic patterns and expression, are not able to transform properly the folic acid in active folate.

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