The company sponsored this important scientific event while its veteran research collaborator Prof. Teodoro Bottiglieri participated in a workshop and panel discussing Advances in Metabolomics.
Gnosis by Lesaffre was a proud sponsor of the FASEB (Federation of American Societies for Experimental Biology) B Vitamins and One-Carbon Metabolism Conference 11-19 Aug, where its long-time research collaborator, Prof. Teodoro Bottiglieri led a panel at the “Advances in Metabolics” workshop.
For over 35 years, the FASEB conference has been the premier venue for scientists and clinicians to discuss the latest research on B-vitamins and one-carbon metabolism, with a focus on recent advancements, public health implications, and fostering future collaborations. According to FASEB, this year’s meeting assembled scientists and clinicians with distinct and complementary backgrounds to present, discuss, and evaluate the latest developments in basic, public health, clinical and applied research in the field to advance medical and public health knowledge. The program covered a wide range of topics, including their global deficiencies, impact on fetal and post-natal health, supplementation, role in epigenomics, and implications for neurological disorders, etc., focusing on cognitive health.
“Studying metabolomics in relation to B-vitamins and one-carbon metabolism disorders is important because these pathways are crucial for DNA function and overall health,” says Prof. Bottiglieri, Program Director of the Center of Metabolomics at Baylor Scott & White Research Institute in Dallas, TX. “Understanding metabolic changes can lead to earlier diagnoses, better treatments, and improved outcomes for neurodegeneration or cardiovascular diseases. In addition, with the advancements made in analytical technology, we are now beginning to better understand the impact of B-vitamin deficiencies on cellular metabolism that results in specific phenotypic expression in individuals that can lead to appropriate therapeutic interventions.”
In 2019, Prof. Bottiglieri received recognition for his monograph, SAMe: Metabolic Function and Health Benefits, which he presented at the Integrative Healthcare Symposium in New York. This in-depth literature review explores the biological roles and health benefits of SAMe, reinforcing Prof. Bottiglieri’s expertise in the field.
A recent study by Prof. Bottiglieri discovered that SAMe (S-Adenosylmethionine, the most important methylating agent in the body) is present in much higher concentrations in breast milk compared to other biofluids, highlighting its crucial role in infant development.[1] This finding could have important implications for breastfeeding and the formulation of infant nutrition products.
“We found that SAMe, crucial for metabolic pathways and neurodevelopment, is present in much higher concentrations in breast milk, likely from breast tissue,” he adds. “This suggests SAMe plays a vital role in infant growth, but more research is needed to fully understand its significance and potential impact on breastfeeding practices and infant formula compositions.”
“Gnosis is proud to remain at the cutting edge of science, receiving research support for key products in our portfolio, including Quatrefolic® active folate and Adonat® Premium SAMe,” says Jean-François Jeanne, Substantiation and Applications Manager at Gnosis. “Prof. Bottiglieri’s groundbreaking work and voice at the FASEB Conference reinforces what we have been trying to accomplish with our ingredients: identifying opportunities to create a healthier global population through correcting nutrient deficiencies.”
References:
1 Lerin C, Bottiglieri T, et al. “Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine.” Nutrients. 2023 Jan; 15(2): 282. Published online 2023 Jan 5. doi: 10.3390/nu15020282
_______