Inflammation is the mechanism of innate immunity, which eliminates the cause of injury. Sometimes, the body's defence system inappropriately triggers inflammation against its own cells, resulting in inflammatory autoimmune diseases. The rising incidences of autoimmune and respiratory conditions, extensive drug development pipeline, and increasing popularity of anti-inflammatory drugs with lesser side effects are the key factors driving the growth of the global anti-inflammatory therapeutics market. In addition, growing awareness about anti-inflammatory therapeutics and government initiatives, in the Asia pacific and LAMEA would further boost the market growth.
According to a report by Allied Market Research, the global market for inflammation and anti-inflammatory products and treatment is expected to reach $106.1 billion by 2020, growing at a CAGR of 6.10% from 2017 to 2021. The anti-inflammatory biologics segment held three-fifths of overall market in 2014. The Asia Pacific market would exhibit the highest CAGR of 8.5% during the forecast period.
Ingredients relieving inflammation
Beta-carotene acts as a powerful antioxidant in the body, helping reduce the build-up of harmful free radicals and prevent oxidative damage to cells while also blocking inflammation. The anti-inflammatory effects of vitamin A and beta-carotene can have far-reaching effects on many aspects of health, as inflammation is at the root of many chronic conditions, ranging from cancer to heart disease and diabetes. Reduced levels of inflammation are also correlated with a lower risk for neurodegenerative diseases like Alzheimer’s and Parkinson’s as well as improvements of inflammatory conditions like rheumatoid arthritis and Crohn’s disease.
Resveratrol supplements may reduce inflammation in individuals with heart disease, insulin resistance, gastritis, ulcerative colitis and other conditions. One study gave people with ulcerative colitis 500mg of resveratrol daily. Their symptoms improved and they had reductions in the inflammation markers CRP, TNF and NF-kB. In another study, resveratrol supplements lowered inflammatory markers, triglycerides and blood sugar in people with obesity.
3. Omega-3 fatty acids
Omega-3 fatty acids can decrease the inflammation associated with diabetes, heart disease, cancer and many other conditions. Two especially beneficial types of omega-3s are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). DHA, in particular, has been shown to have anti-inflammatory effects that reduce cytokine levels and promote gut health. It may also decrease the inflammation and muscle damage that occur after exercise. In one study, levels of the inflammation marker IL-6 were 32% lower in people who took 2 grams of DHA, compared to a control group.
4. Chondroitin Sulfate
Chondroitin sulfate also has anti-inflammatory, accelerate wound healing and anti-tumour effects.
Chondroitin may help heal wounds. A few studies have been performed on animals to assess the efficacy of chondroitin in promoting wound healing. In one study performed on white rabbits, researchers noted that application of chondroitin hydrogel accelerated wound healing at the four-day endpoint.
5. Vitamin C
This antioxidant helps get rid of free radicals that can damage cells and tissue, which means fewer triggers for inflammation. The vitamin C has a major part in fighting inflammation, especially when it comes to heart diseases. It does that by releasing the free radicals that can produce damage to the body structures. Decreases the dangerous LDL cholesterol and by that it decreases the chances of hypertension at the same time.
6. Vitamin D
The ‘Sunshine Vitamin’ is in the group of anti-inflammatory vitamins. The vitamin D can modulate the immune system with his beneficial effects against the inflammatory disorders. It helps in the absorption of calcium and phosphorus from the food we eat and prevent the loss of calcium in the kidneys. This vitamin is essential for the normal mineralisation of the bones and teeth. In the lab, this vitamin shows a significant anti-inflammatory effect on cells. There's also some evidence that D can lessen the ongoing pain from inflammation.
7. Vitamin E
Vitamin E is considered as one of the most effective antioxidants in the body that can eliminate the free radicals. It’s one of the propagators of inflammation. This vitamin helps to prevent the coronary heart disease by limiting the oxidation of LDL cholesterol. With the selenium given at the same time the vitamin C is used to aid the treatment of various inflammation conditions in our body.
8. Alpha-Lipoic Acid
Several studies show that Alpha-Lipoic Acid reduces the inflammation linked to insulin resistance, cancer, liver disease, heart disease and other disorders. Additionally, alpha-lipoic acid may help reduce blood levels of several inflammatory markers, including IL-6 and ICAM-1.
9. Cinnamon Extract
The antioxidants in cinnamon can help relieve inflammation, which may help lower the risk of heart disease, cancer, cognitive decline and more. Researchers have identified many different types of flavonoids in cinnamon, all of which are highly effective at fighting dangerous inflammation levels throughout the body. Because cinnamon lowers swelling and prevents inflammation, it can also be beneficial in pain management, with studies showing that cinnamon helps to reduce muscle soreness, decrease menstrual pain, lessen the severity of allergic reactions and help relieve other age-related symptoms of pain as well.
10. Senna Leaf Extract
The Senna plant may be able to effectively treat haemorrhoids or inflammation of the veins surrounding the anal passage, which usually results when there is excessive pressure. By reducing inflammation, it may promote quick healing and easier passage of stool.
11. Rosemary Extract
At higher doses, rosemary extracts decreased the production of inflammatory molecules (such as IL-1β, COX-1, TNFα, and iNOS) in human cells. It decreases the production of nitric oxide, a product of inflammation. Rosemary essential oil significantly reduced white blood cell (leukocyte) rolling, another process of the inflammatory response.
12. Ginkgo Biloba Extract
Years of animal and test-tube research shows that ginkgo extract can reduce markers of inflammation in both human and animal cells in a variety of disease states. Some specific conditions in which ginkgo extract has shown to reduce inflammation include: arthritis, irritable bowel disease (IBD), cancer, heart disease and strokes.
13. Olive Extract
Olive oil has been linked to heart health and longevity. It's rich in monounsaturated fats that are good for your blood vessels and has polyphenols that work as antioxidants to protect the cells in your body. Olive oil helps reduce inflammation, reduces high cholesterol, and it's possible that some of the polyphenols may help prevent some forms of cancer, so it's an amazing oil to add to your kitchen.
Curcumin can decrease inflammation in diabetes, heart disease, inflammatory bowel disease and cancer, to name a few. Curcumin also appears to be very beneficial for reducing inflammation and improving symptoms of osteoarthritis and rheumatoid arthritis. One study found that when 80 people with solid cancerous tumors were given 150mg of curcumin, most of their inflammatory markers decreased much more than those in the control group..
15. Ginger Extract
Two components of ginger, gingerol and zingerone, may reduce the inflammation linked to colitis, kidney damage, diabetes and breast cancer. There's also evidence suggesting ginger supplements can decrease inflammation and muscle soreness after exercise.
16. Horse Chestnut Extract
Horse Chestnut Extract has potent anti-inflammatory properties. Aescin is a component in horse chestnut extract with anti-inflammatory properties. It has been found to reduce inflammation related to injury, venous insufficiency, and swelling. A review of 17 studies observed that horse chestnut seed extract could help reduce inflammation and swelling in the legs and feet related to CVI.
Johnson & Johnson, Boehringer Ingelheim, Amgen, Inc., Sanofi Aventis, Abbott Laboratories, and AstraZeneca are some of the leading companies operating in the global market for anti-inflammatory therapeutics. Kangcare Bioindustry is involved in providing high quality ingredients, like Oilgin Algae Oil DHA, Purerbe Herbal Extracts, Vitamins to global anti-inflammatory products manufacturers and Kangcare is gaining reputation in global market.