With its enhanced, proven bioefficacy, GliSODin - one of the most powerful antioxidants - better prepares skin for the sun's rays, fighting against its damage and boosting the effects of sun creams, alongside its actions against all other facets of ageing.
Several ways of improving the bioavailability of exogenous superoxide dismutase (SOD) have been tested, from the extra protection provided by coating to complexation systems. Developed and supplied by Isocell, and marketed in Europe by Becarre Natural, GIiSODin is an SOD melon extract processed into a specific matrix of gliadin. It not only offers enteric protection, but also acts as a real SOD vehicle or conveyer due to its specific bioadhesive properties, which work with the epithelial cells of the small intestine - the place where SOD must be assimilated to be effective. Its bioavailability and bioefficacy have been proved in published clinical studies.
GliSODin - the bioavailable SOD - can be included in all formulations, from tablets to capsules and drinks. Studies have shown the positive effects that orally administered GliSODin has on skin - sun protection, oxidative stress and anti-ageing - cardiovascular health and the immune system, in addition to its other related properties. The properties of oral GliSODin are supported by more than 25 clinical studies, which are often used as a point of reference.
GliSODin acts as a shield against oxidative stress by preparing the body to protect against UV attacks.
In addition to the cellular antioxidant protection demonstrated repeatedly, a double-blind study showed that supplementation with GliSODin reduces the intensity and duration of skin redness for fair, healthy skin that has been exposed to UV radiation. GliSODin significantly increased the minimal erythema dose, thus properly preparing the skin for sun exposure while improving tan speed and quality.
Another open clinical study was performed on 150 photosensitive subjects who were supplemented with GliSODin, in combination with a regular application of sunscreen during the summer period. It found that 73% reported the synergy between sun cream and GliSODin prevented the appearance of solar allergies (benign summer lucites).
More recently, a clinical study showed that the GliSODin formula significantly reduced hyperpigmentation (-25%) and pigment macules (-14%) caused by the sun after 90 days of supplementation. It has also been proposed for GliSODin to help fight against the adverse effects of radiotherapy - and there are studies to demonstrate its benefits after skin surgery.
GliSODin protects the cells against the negative effects of oxidative stress by remaining active in the intestinal passage by engaging the internal system of antioxidant enzyme defences and limiting cell death, which results from oxidative stress.
GliSODin has also shown its beneficial effects in an in-vivo study that used ultrasound imaging for the analysis of the intima-media thickness (IMT) of the carotid artery. A number of studies have highlighted the relationship between carotid IMT and the presence and severity of atherosclerosis - a major risk factor for cardiovascular disease. Complex SOD allowed a reduction in the progression of IMT, as well as lipid oxidation decrease.
GliSODin could also reduce the loss of cognitive function linked to stress, according to a published animal study from Japan, which showed lower levels of oxidative stress and better performances in maze memory.
