cannhelp - Water-soluble CBD: myths versus facts

It is important to understand that the human body consists mostly of water, and substances that dissolve in water can therefore be absorbed more easily by the body. This, in pharmaceutical terms, is called bioavailability.

The bioavailability of cannabidiol (CBD)

A substance that is injected intravenously (directly into the bloodstream) has a bioavailability of 100%. For other ways of intake, such as oral, nasal or rectal, a relative bioavailability is computed based on the 100% bioavailability. Basically, the assumption is that the greater the bioavailability of the active substance, the more it can be found where it should be to have an effect. The question remains: is more always better? And contrary to one's gut feeling, the answer is no, definitely not always.

Since CBD is not usually water-soluble, but fat-soluble, the relative bioavailability through oral intake is rather poor (~10%); however, certain processes may influence the solubility of CBD. In combination with solubilisers, such as alcohol, CBD may have a higher relative bioavailability than when it's in its natural form.

What are the solubilisers of CBD?

There are different solubilisers, such as alcohol and surfactants or lecithin, which come from milk. To become more immersed in the chemistry class, there are further methods that can influence the bioavailability of a substance; for example, a CBD molecule can interact with other water-soluble molecules when covered in sugar molecules, which is called sugar coating. Another possibility is dispersion, a process where molecules that are otherwise undissolved, such as salts or as crystalline solids, are atomised into very small parts. Pure CBD is a crystalline substance. Atomisation allows these tiny CBD particles to float in water.

The methods used to improve solubility depend on the resources, such as the patents, machines and money, companies have at their disposal. The formulation that results in a certain amount of bioavailability has not been determined yet, since only a few research results have been made publicly available.

Do not forget that alcohol content, solubilisers and sugar also play a role when users consume any form of CBD, because these ingredients can change the effect of the CBD product. The simplest example is sugar coating, which can be a problem for diabetics.

Do consumers buy water-based CBD or stick to CBD oils?

To summarise: less is often more. If consumers already achieve good results using a CBD oil, then they do not have to resort to other, possibly less effective products - especially as long as no research results are available. In addition, fullspectrum CBD oils also contain other effective ingredients like terpenes and flavonoids that benefit users. In water-soluble isolate products, however, there is only pure CBD. Cannexol Aqua, from cannhelp, is entirely tetrahydrocannabinol-free.

Whether users are looking for an oil or water-based CBD product, they should first discuss which one to take with their doctor or pharmacist. The products work differently and are suitable for specific cases.

More information can be found on the product descriptions for Cannexol 5, 10 and 25% CBD oils, as well as the company's website for Cannexol Aqua 2.5% CBD.

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